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ACETYLCHOLINE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A neurotransmitter that is a derivative of choline; released at the ends of nerve fibers in the somatic and parasympathetic nervous systems
Classified under:
Hypernyms ("acetylcholine" is a kind of...):
neurotransmitter (a neurochemical that transmits nerve impulses across a synapse)
Context examples:
Neuronal acetylcholine receptor subunit alpha-3 (503 aa, ~57 kDa) is encoded by the human CHRNA3 gene.
(Neuronal Acetylcholine Receptor Subunit Alpha-3, NCI Thesaurus)
Neuronal acetylcholine receptor subunit alpha-5 (468 aa, ~53 kDa) is encoded by the human CHRNA5 gene.
(Neuronal Acetylcholine Receptor Subunit Alpha-5, NCI Thesaurus)
Oxybutynin chloride exerts its antimuscarinic effect on bladder smooth muscle by blocking muscarinic receptors in smooth muscle, thereby inhibiting acetylcholine binding.
(Oxybutynin Chloride, NCI Thesaurus)
Oxybutynin blocks muscarinic receptors in smooth muscle, hence inhibiting acetylcholine binding and subsequent reduction of involuntary muscle contractions.
(Oxybutynin, NCI Thesaurus)
Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited.
(Oxycodone, NCI Thesaurus)
Pancuronium bromide competitively binds to the nicotinic receptor at the neuromuscular junction, thereby preventing acetylcholine binding and resulting in skeletal muscle relaxation and paralysis.
(Pancuronium Bromide, NCI Thesaurus)
Piperazine citrate is a gamma-aminobutyric acid GABA receptor agonist and blocks the activity of acetylcholine at the neuromuscular junction thereby altering neuronal cell membrane permeability and causing hyperpolarization.
(Piperazine Citrate, NCI Thesaurus)
Although the mechanism of action has not been determined, orphenadrine appears to block muscarinic acetylcholine receptors as well as N-methyl-D-aspartate (NMDA) receptors in the central nervous system (CNS).
(Orphenadrine, NCI Thesaurus)
It is released by the vascular endothelium and mediates the relaxation induced by some vasodilators such as acetylcholine and bradykinin.
(Nitric Oxide, NLM, Medical Subject Headings)
Nicotine's CNS-stimulating activities may be mediated through the release of several neurotransmitters, including acetylcholine, beta-endorphin, dopamine, norepinephrine, serotonin, and ACTH.
(Nicotine, NCI Thesaurus)
