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ACTION POTENTIAL
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The local voltage change across the cell wall as a nerve impulse is transmitted
Classified under:
Hypernyms ("action potential" is a kind of...):
impulse; nerve impulse; nervous impulse; neural impulse (the electrical discharge that travels along a nerve fiber)
Context examples:
Moricizine hydrochloride blocks the rapid flow of sodium ions into the myocardial cell during phase 0 of the action potential.
(Moricizine Hydrochloride, NCI Thesaurus)
Mexiletine exerts its antiarrhythmic effect by inhibiting the inward sodium current in cardiac cells, thereby reducing the rate of rise of the cardiac action potential (phase 0) and decreases automaticity in the Purkinje fibers.
(Mexiletine, NCI Thesaurus)
This slows the impulse conduction through the AV node and prolongs the duration of the action potential of normal cardiac cells in atrial and ventricular tissues.
(Disopyramide Phosphate, NCI Thesaurus)
The neuromuscular junction communicates action potentials from motor neurons across a synapse to skeletal muscle.
(Botulin Pathway, NCI Thesaurus/BIOCARTA)
Agents used for the treatment or prevention of cardiac arrhythmias; they may effect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers.
(Antiarrhythmic Agent, NCI Thesaurus)
As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period.
(Amiodarone, NCI Thesaurus)
Amifampridine inhibits potassium channel efflux, increasing the duration of the action potential, which results in an increase in the duration of calcium channel opening and enhanced acetylcholine (ACh) release.
(Amifampridine, NCI Thesaurus)
Its myocardial effects include a prolongation of action potential as well as refractory period.
(Bretylium Tosylate, NCI Thesaurus)
This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and leads to a decrease in neuronal excitability.
(Alprazolam, NCI Thesaurus)
This slows the rate and amplitude of phase 0 depolarization and thus prolongs the duration of the action potential, thereby reducing cell excitability and conduction velocity.
(Disopyramide, NCI Thesaurus)
