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ACTIVATION
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I. (noun)
Sense 1
Meaning:
Making active and effective (as a bomb)
Classified under:
Nouns denoting acts or actions
Hypernyms ("activation" is a kind of...):
beginning; commencement; start (the act of starting something)
Antonym:
deactivation (the act of deactivating or making ineffective (as a bomb))
Derivation:
activate (make active or more active)
Sense 2
Meaning:
The activity of causing to have energy and be active
Synonyms:
activating; activation; energizing
Classified under:
Nouns denoting acts or actions
Hypernyms ("activation" is a kind of...):
activity (any specific behavior)
Hyponyms (each of the following is a kind of "activation"):
electrification (the activity of thrilling or markedly exciting some person or group)
animation; invigoration; vivification (the activity of giving vitality and vigour to something)
Sense 3
Meaning:
Stimulation of activity in an organism or chemical
Classified under:
Nouns denoting natural processes
Hypernyms ("activation" is a kind of...):
stimulation ((physiology) the effect of a stimulus (on nerves or organs etc.))
Hyponyms (each of the following is a kind of "activation"):
indweller (activation by an inner spirit or force or principle)
Antonym:
inactivation (the process of rendering inactive)
Derivation:
activate (make (substances) radioactive)
activate (aerate (sewage) so as to favor the growth of organisms that decompose organic matter)
activate (make more adsorptive)
activate (put in motion or move to act)
Context examples:
After activation, it can then proliferate and differentiate into memory cells, antibody-secreting cells or plasma cells.
(Activated Lymphocyte, NCI Thesaurus)
Wave-1 activation by Rac1 and Nck releases Wave-1 with Hspc300 to activate actin Y branching and polymerization by Arp2/3.
(Actin Branching Pathway, NCI Thesaurus/BIOCARTA)
This protein is involved in the activation of apoptosis.
(Activator of Apoptosis Harakiri, NCI Thesaurus)
Both aberrant and constitutive activation of signal transduction molecules are found in about 50% of primary AML bone marrow samples, and seem to contribute to the increased proliferation and apoptosis resistance.
(Acute Myeloid Leukemia Pathway, NCI Thesaurus/KEGG)
AP1903 binds to the drug binding domain, leading to iMC oligomerization and activation of iCD40 and MyD88-mediated signaling in iMC-expressing DCs.
(Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201, NCI Thesaurus)
In modern times, disturbances associated with land use are believed to be a dominant factor contributing to the activation of stabilized vegetated dunes in drylands.
(Sleeping sands of the Kalahari awaken after more than 10,000 years, NSF)
MEK, a dual-specificity threonine/tyrosine kinase that plays a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway, is frequently upregulated in a variety of tumor cell types.
(MEK Inhibitor WX-554, NCI Thesaurus)
Upon oral administration, MEK/Aurora kinase inhibitor BI 847325 selectively binds to and inhibits the activity of MEK, which both prevents the activation of MEK-dependent effector proteins and inhibits growth factor-mediated cell signaling.
(MEK/Aurora Kinase Inhibitor BI 847325, NCI Thesaurus)
Furthermore, this agent also inhibits tumor cell migration and invasion by inhibiting matrix metalloproteinase-9 (MMP-9) expression which is mediated through the suppression of transcription activator protein-1 (AP-1) activation.
(Metformin hydrochloride, NCI Thesaurus)
A non-pressurized dosage form consisting of valves which allow the dispensing of a specified quantity of spray upon each activation.
(Metered Spray Dosage Form, NCI Thesaurus/CDISC)
