AFP464

Definition 1

A substance being studied in the treatment of cancer. AFP464 kills cancer cells or stops them from dividing. It is a type of aminoflavone. (NCI Dictionary)

Definition 2

A synthetic lysyl prodrug of the amino-substituted flavone derivate aminoflavone with antiproliferative and antineoplastic activities. AFP464 is rapidly converted to aminoflavone in plasma. Aminoflavone activates the aryl hydrocarbon receptor (AhR) signaling pathway leading to an increase in cytochrome P450 1A1 (CYP1A1) and cytochrome P450 1A2 (CYP1A2) expression and, to a lesser extent, an increase in cytochrome P450 1B1 (CYP1B1) expression. Subsequently, aminoflavone is metabolized to toxic metabolites by the cytochromome P450 enzymes that it induces; these toxic metabolites covalently bind to DNA, resulting in the phosphorylation of p53, the induction of the p53 downstream target p21Waf1/Cip1, and apoptosis. Pulmonary toxicity may be dose-limiting. (NCI Thesaurus)

YOU MAY ALSO LIKE

AFP wt Allele

Human AFP wild-type allele is located within 4q11-q13 and is approximately 20 kb in length. This allele, which encodes alpha-fetoprotein, plays a…

AFP Gene Hepatocellular Carcinoma Vaccine

A cancer vaccine composed of naked plasmid DNA of the gene for the tumor-associated antigen alpha-fetoprotein (AFP), a macromolecule that acts as…

AFP Gene

This gene plays a role in fetal progression.

AFP

A protein normally produced by a fetus. AFP levels are usually undetectable in the blood of healthy adult men or women (who…

Aflodac

Other name for sulindac.

Aflatoxins-Related Hepatocellular Carcinoma

A hepatocellular carcinoma that develops following exposure to aflatoxin.