| Health / Medical Topics |
Atypical Fibroxanthoma
An intermediate cutaneous fibrohistiocytic neoplasm, characterized by pleomorphic spindle cells, usually affecting the actinic-damaged skin of the elderly. The tumor presents as a single cutaneous nodule which is often ulcerated. Microscopically, it is characterized by the presence of highly atypical cytologic features, pleomorphism and abundant mitotic figures. It is regarded by many experts as a superficial form of malignant fibrous histiocytoma. The vast majority of patients have an excellent prognosis following conservative therapy. Recurrences are infrequent, and metastasis is rare. (NCI Thesaurus)
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