Bcl-2-Modifying Factor

Bcl-2-like protein 2 (193 aa, ~21 kDa) is encoded by the human BCL2L2 gene. This protein plays a role the regulation of…

Bcl-2-like protein 11 (198 aa, ~22 kDa) is encoded by the human BCL2L11 gene. This protein is involved in the induction of…

Bcl-2-like protein 1 (233 aa, ~26 kDa) is encoded by the human BCL2L1 gene. This protein is involved in the modulation of…

Bcl-2-interacting killer (160 aa, ~18 kDa) is encoded by the human BIK gene. This protein plays a role in apoptosis.

Bcl-2-binding component 3 (193 aa, ~21 kDa) is encoded by the human BBC3 gene. This protein plays a role in the regulation…

An orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. GDC-0199 mimics BH3-only proteins, the native…