Library / English Dictionary

    BETA-LACTAMASE

    Pronunciation (US): Play  (GB): Play

     I. (noun) 

    Sense 1

    Meaning:

    Enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibioticplay

    Synonyms:

    beta-lactamase; penicillinase

    Classified under:

    Nouns denoting substances

    Hypernyms ("beta-lactamase" is a kind of...):

    enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)

    Credits

     Context examples: 

    A combination formulation of the antibiotic piperacillin and the beta-lactamase inhibitor tazobactam with antibacterial activity.

    (Piperacillin-tazobactam, NCI Thesaurus)

    Clavulanic acid is a beta-lactamase inhibitor, which prevents the beta-lactamase enzyme destroying penicillin; it is already used as a medicine to treat kidney infections during pregnancy.

    (Widely-available antibiotics could be used in the treatment of ‘superbug’ MRSA, University of Cambridge)

    Ampicillin is stable against hydrolysis by a variety of beta-lactamases, therefore, can be used in wide range of gram-positive and -negative infections.

    (Ampicillin, NCI Thesaurus)

    A combination formulation of the sodium salts of the antibiotic ampicillin and the beta-lactamase inhibitor sulbactam with antibacterial activity.

    (Ampicillin Sodium/Sulbactam Sodium, NCI Thesaurus)

    This species is indole positive, but lipase, catalase, urease and nitrate negative, hydrolyzes esculin and gelatin, and is beta-lactamase positive thus resistant to penicillin G, vancomycin, ceftizoxime, cefotetan.

    (Bacteroides nordii, NCI Thesaurus)

    This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms.

    (Aztreonam, NCI Thesaurus)

    This agent undergoes a color change as its amide bond is hydrolyzed by beta-lactamase, making it useful as a reagent in beta-lactamase activity studies.

    (Nitrocefin, NCI Thesaurus)

    The sodium salt form of cefoperazone and a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity.

    (Cefoperazone Sodium, NCI Thesaurus)

    A combination of the semisynthetic broad-spectrum antibiotic amoxicillin and the beta-lactamase enzyme inhibitor clavulanate potassium.

    (Amoxicillin-clavulanate potassium, NCI Thesaurus)

    A fixed combination of Amoxicillin and Clavulanic Acid, which inhibits beta-lactamase, a bacterial enzyme that inactivates amoxicillin.

    (Amoxicillin-Clavulanic Acid, NCI Thesaurus)


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