Beta-Microseminoprotein

Encoded by human MSMB Gene (Ig Binding Factor Family, Beta-Microseminoprotein Family), 12.8 kD (precursor) secreted Beta-Microseminoprotein (isoforms PSP94 and PSP57) is expressed in prostate, liver, kidney, breast, penis, pancreas, esophagus, stomach, duodenum, colon, trachea, lung, salivary glands, and fallopian tube. PSP94 is also expressed in lung and breast; PSP57 is found in kidney and bladder. The 94-amino acid seminal protein is derived from a pre-polypeptide of 114 amino acids. Specific receptors are found on spermatozoa and in the prostate. The protein may have inhibin-like activity; it may act as an autocrine paracrine factor in uterine, breast, and other female reproductive tissues and may inhibit pituitary secretion of FSH. (from Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)

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