BI 2536

Definition 1

A substance being studied in the treatment of cancer. It prevents cells from dividing and may block the growth of some tumors. It is a type of mitotic inhibitor. (NCI Dictionary)

Definition 2

A small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1), resulting in mitotic arrest, disruption of cytokinesis, and apoptosis in susceptible tumor cell populations. Plk1, a serine/threonine-protein kinase, is a key regulator of multiple processes fundamental to mitosis and cell division. (NCI Thesaurus)

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