Birinapant

A synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, birinapant selectively binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 (cIAP1) and 2 (cIAP2), with a greater effect on cIAP1 than cIAP2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells and inactivate the nuclear factor-kappa B (NF-kB)-mediated survival pathway. IAPs are overexpressed by many cancer cell types. They are able to suppress apoptosis by binding to, via their baculoviral lAP repeat (BIR) domains, and inhibiting active caspases-3, -7 and -9. IAP overexpression promotes both cancer cell survival and chemotherapy resistance. (NCI Thesaurus)

YOU MAY ALSO LIKE

Biricodar Dicitrate

The dicitrate salt of a synthetic pipecolinate derivative with potential chemosensitizing activity. Biricodar binds directly to the plasma membrane drug-efflux pumps P-glycoprotein…

Biricodar

A pipecolinate derivative. Functioning as a modulator of P-glycoprotein (P-gp) and multidrug resistance protein (MRP-1), biricodar restores drug sensitivity to cells…

Bird Flu

Birds, just like people, get the flu. Bird flu viruses infect birds, including chickens, other poultry, and wild birds such as…

Bird Fancier's Lung

A respiratory disorder due to an acquired hypersensitivity to the dust of bird droppings.

BIRC7 wt Allele

Human BIRC7 wild-type allele is located in the vicinity of 20q13.3 and is approximately 5 kb in length. This allele, which encodes…

BIRC7 Gene

This gene regulates apoptosis through dual transcriptional activation pathways.