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BIVALENT
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Used of homologous chromosomes associated in pairs in synapsis
Synonyms:
bivalent; double
Classified under:
Attribute:
valence; valency ((biology) a relative capacity to unite or react or interact as with antigens or a biological substrate)
Domain category:
genetic science; genetics (the branch of biology that studies heredity and variation in organisms)
Antonym:
multivalent (used of the association of three or more homologous chromosomes during the first division of meiosis)
univalent (used of a chromosome that is not paired or united with its homologous chromosome during synapsis)
Sense 2
Meaning:
Having a valence of two or having two valences
Synonyms:
bivalent; divalent
Classified under:
Relational adjectives (pertainyms)
Domain category:
chemical science; chemistry (the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions)
Pertainym:
valence ((chemistry) a property of atoms or radicals; their combining power given in terms of the number of hydrogen atoms (or the equivalent))
Context examples:
A bivalent cancer vaccine comprised of a modified vaccinia virus Ankara (MVA) strain encoding human mucin 1 (MUC1) and interleukin-2 (IL-2) with potential immunostimulating and antineoplastic activities.
(MVA-MUC1-IL2 Vaccine, NCI Thesaurus)
A bivalent human papillomavirus (HPV) therapeutic vaccine containing recombinant inactivated adenylate cyclase (CyaA) from Bordetella pertussis carrying a sequence encoding the E7 antigen of both HPV16 and 18, with potential immunostimulatory and antiviral properties.
(Bivalent HPV16/18 Therapeutic Cervical Cancer Vaccine, NCI Thesaurus)
A poloxamer-formulated, bivalent DNA vaccine containing two plasmids encoding both the human cytomegaloviral (CMV) tegument phosphoprotein 65 (pp65), a major internal matrix protein, and glycoprotein B (gB), an important CMV component responsible for attachment and entry into cells, with potential immunostimulatory properties.
(CMVpp65/gB Plasmid Vaccine ASP0113, NCI Thesaurus)
A bivalent fusion protein consisting of disulfide-stabilized Fv fragments of an anti-HER2 (erbB2) monoclonal antibody (e23) and a truncated version of the M(r) 38 fragment of Pseudomonas exotoxin that lacks the toxin's cell binding domain.
(Erb-38 immunotoxin, NCI Thesaurus)
Also called recombinant human papillomavirus bivalent vaccine.
(Cervarix, NCI Dictionary)
The bromodomain containing transcription complexes SWI/SNF and TFIID are recruited to the promoter via bivalent interactions between the enhanceosome and specifically acetylated histone N termini.
(IFN-Beta Enhancer Pathway, NCI Thesaurus/BIOCARTA)
Upon administration of bivalent HPV16/18 therapeutic cervical cancer vaccine, the expressed proteins may activate cell-mediated immunity and induce both cytotoxic CD8+ T cells and CD4+ helper T cells against the target antigens HPV16-E7 and HPV18-E7, which leads to HPV viral clearance.
(Bivalent HPV16/18 Therapeutic Cervical Cancer Vaccine, NCI Thesaurus)
