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    BREAKDOWN

    Pronunciation (US): Play  (GB): Play

     I. (noun) 

    Sense 1

    Meaning:

    The act of disrupting an established order so it fails to continueplay

    Example:

    his warning came after the breakdown of talks in London

    Synonyms:

    breakdown; dislocation

    Classified under:

    Nouns denoting acts or actions

    Hypernyms ("breakdown" is a kind of...):

    disruption; perturbation (the act of causing disorder)

    Derivation:

    break down (make ineffective)

    Sense 2

    Meaning:

    An analysis into mutually exclusive categoriesplay

    Synonyms:

    breakdown; partitioning

    Classified under:

    Nouns denoting cognitive processes and contents

    Hypernyms ("breakdown" is a kind of...):

    analysis; analytic thinking (the abstract separation of a whole into its constituent parts in order to study the parts and their relations)

    Hyponyms (each of the following is a kind of "breakdown"):

    resolution; resolving (analysis into clear-cut components)

    Derivation:

    break down (make a mathematical, chemical, or grammatical analysis of; break down into components or essential features)

    Sense 3

    Meaning:

    A cessation of normal operationplay

    Example:

    there was a power breakdown

    Synonyms:

    breakdown; equipment failure

    Classified under:

    Nouns denoting natural events

    Hypernyms ("breakdown" is a kind of...):

    failure (an event that does not accomplish its intended purpose)

    Hyponyms (each of the following is a kind of "breakdown"):

    brake failure (brakes fail to stop a vehicle)

    engine failure (engine does not run)

    dud; misfire (an explosion that fails to occur)

    outage (a temporary suspension of operation (as of computers))

    power failure; power outage (equipment failure resulting when the supply of power fails)

    fault ((electronics) equipment failure attributable to some defect in a circuit (loose connection or insulation failure or short circuit etc.))

    Derivation:

    break down (stop operating or functioning)

    Sense 4

    Meaning:

    (biology) the process of decay caused by bacterial or fungal actionplay

    Synonyms:

    breakdown; decomposition; putrefaction; rot; rotting

    Classified under:

    Nouns denoting natural processes

    Hypernyms ("breakdown" is a kind of...):

    decay (the process of gradually becoming inferior)

    Domain category:

    biological science; biology (the science that studies living organisms)

    Derivation:

    break down (separate (substances) into constituent elements or parts)

    Sense 5

    Meaning:

    A mental or physical breakdownplay

    Synonyms:

    breakdown; crack-up

    Classified under:

    Nouns denoting stable states of affairs

    Hypernyms ("breakdown" is a kind of...):

    collapse; prostration (an abrupt failure of function or complete physical exhaustion)

    Hyponyms (each of the following is a kind of "breakdown"):

    nervous breakdown (a severe or incapacitating emotional disorder)

    Derivation:

    break down (collapse due to fatigue, an illness, or a sudden attack)

    break down (lose control of one's emotions)

    Credits

     Context examples: 

    A finding of leakage of bile due to breakdown of a biliary anastomosis (surgical connection of two separate anatomic structures).

    (Biliary Anastomotic Leakage, NCI Thesaurus/CTCAE)

    A dark orange, yellow pigment that is the product of the breakdown of iron in the blood; it is conjugated in the liver and excreted in the bile.

    (Bilirubin, NCI Thesaurus)

    C. testosteroni is found in soil and water, is used in industry to breakdown industrial by-products, and is rarely found to be pathogenic in humans.

    (Comamonas testosteroni, NCI Thesaurus)

    The breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function.

    (Creatinine, NCI Thesaurus)

    Leakage due to breakdown of a pancreatic anastomosis.

    (Pancreatic Anastomotic Leakage, NCI Thesaurus)

    Activation of cyclin B-Cdc2 causes breakdown of the germinal vesicle and the initiation of oocyte maturation.

    (Oocyte Maturation Pathway, NCI Thesaurus/BIOCARTA)

    A finding of leakage due to breakdown of a pancreatic anastomosis (surgical connection of two separate anatomic structures).

    (Pancreatic Anastomotic Leakage, NCI Thesaurus/CTCAE)

    The PEG moiety inhibits proteolytic breakdown and clearance of IFN-a2b, which prolongs its half-life, extends the duration of its therapeutic effects and allows less frequent dosing.

    (PEG-Proline-Interferon Alfa-2b, NCI Thesaurus)

    The PEG moiety inhibits proteolytic breakdown and clearance of AM0010, which prolongs its half-life, extends the duration of its therapeutic effects and allows less frequent dosing.

    (Pegylated Recombinant Human Interleukin-10 AM0010, NCI Thesaurus)

    The lysis (breakdown) of cancer cells.

    (Oncolysis, NCI Dictionary)


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