Library / English Dictionary

CHECKPOINT

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

A place (as at a frontier) where travellers are stopped for inspection and clearance

Classified under:

Nouns denoting spatial position

Hypernyms ("checkpoint" is a kind of...):

stop (a spot where something halts or pauses)

Credits

 Context examples: 

It may do this in multiple ways from holding the cell at a checkpoint until repairs can be made to causing the cell to enter apoptosis if the damage cannot be repaired.

(p53 Signaling Pathway BioCarta, NCI Thesaurus/BIOCARTA)

This allele, which encodes partner and localizer of BRCA2 protein, may play roles in the repair of damaged DNA and DNA damage-induced checkpoints.

(PALB2 wt Allele, NCI Thesaurus)

This protein may play roles in cell cycle checkpoints and the repair of damaged DNA resolved by recombination.

(Partner and Localizer of BRCA2, NCI Thesaurus)

This pathway is thought to play a critical role in DNA repair, V(D)J recombination and cell cycle checkpoints.

(Phosphatidylinositol 3 Kinase, NCI Thesaurus/LocusLink)

p27/Kip1 regulates the cell cycle by inhibiting the checkpoint kinase cdk2/cyclin E and blocking cell cycle progression through the G1-S transition.

(p27 Regulation Pathway, NCI Thesaurus/BIOCARTA)

Tyrosine kinase oncogenes exhibit aberrant gene expression, resulting in elevated levels of their protein products which disrupts mitotic checkpoints.

(Oncogenes, Tyrosine-Kinase, NCI Thesaurus)

It functions in diverse aspects of the cellular response to double strand breaks (DSBs), including the detection of DNA damage, the activation of cell cycle checkpoints, and DSB repair.

(MRE11/RAD50 Double-Strand Break Repair Complex, NCI Thesaurus/from OMIM)

This gene plays a role in DNA repair and cell cycle checkpoints.

(NBN Gene, NCI Thesaurus)

This allele, which encodes nibrin protein, is involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

(NBN wt Allele, NCI Thesaurus)

Serine phosphorylation by ATM is linked to S-phase checkpoint activation.

(Nibrin, NCI Thesaurus)