Health / Medical Topics

    ChIP-On-Chip

    A molecular genetic technique that combines chromatin immunoprecipitation (ChIP) with DNA microarray technology to find candidate binding sites of DNA-associated proteins in a biological specimen. First, crosslinked protein-DNA complexes are isolated using ChIP. Next, the crosslinks are broken, the proteins are removed and the purified DNA is amplified, denatured and labeled with a fluorescent tag. The labeled, denatured DNA fragments are applied to a DNA microarray where they can hybridize to their complementary DNA sequence. After hybridization occurs, the microarray chip is imaged and the captured fluorescence signals from the array are normalized and subjected to statistical analysis. Finally, validated positive spots on the microarray can predict which DNA sequences interact with the protein of interest. (NCI Thesaurus)




    YOU MAY ALSO LIKE

    Derived from a cross between a Chinese hamster and Syrian hamster.
    Derived from a cross between a Chinese hamster and a Syrian hamster, with a golden-colored coat.
    The Chinese Shar-Pei is a heavily wrinkled dog with a large head, though dogs with smaller heads and tighter looking skins do…
    The root of this plant has been used in some cultures to treat certain medical problems. It may have anti-inflammatory and anticancer…
    In traditional Chinese medicine, meridians are channels that form a network in the body, through which qi (vital energy) flows. Blocked qi…
    Herbs used in Chinese Herbal Therapy for toxicity attenuation.

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact