Health / Medical Topics

    Cintredekin Besudotox

    Definition 1

    A recombinant chimeric protein with potent antitumor activity. Cintredekin besudotox is composed of interleukin-13 (IL13), a pleiotropic immunoregulatory cytokine, linked to a mutated form of pseudomonas exotoxin A; this agent targets and kills tumor cells that express the IL13 receptor (IL13R).The IL13 moiety attaches to the IL13R on the tumor cell membrane, facilitating the entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI Thesaurus)

    Definition 2

    A substance being studied in the treatment of cancer. It is made by combining interleukin-13 with a toxin from Pseudomonas bacteria. It is a type of recombinant chimeric protein. (NCI Dictionary)




    YOU MAY ALSO LIKE

    A bufadienolide compound extracted from the dried venom secreted by the parotid glands of toads and one of the glycosides in the…
    The oils extracted from the leaves or bark of Cinnamomum verum. Cinnamon bark oil is used as a flavoring, in parfumary, and…
    The oil extracted from the leaves of Cinnamomum zeylanicum. Cinnamon leaf oil is used primarily in aromatherapy.
    A characteristic of a medicinal product, specifying that its most predominant agreeable savor detected by the unified sensation of taste and olfactory…
    The oil extracted from the bark of Cinnamomum zeylanicum. Cinnamon bark oil has antibacterial and antifungal properties but is an irritant to…
    The oil extracted from the bark of Cinnamomum loureiroi. Saigon cinnamon bark oil is used primarily in aromatherapy.

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact