| Library / English Dictionary |
CONSTITUTIVE
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Constitutional in the structure of something (especially your physical makeup)
Synonyms:
constituent; constitutional; constitutive; organic
Classified under:
Similar:
essential (basic and fundamental)
Context examples:
The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling.
(Basal Cell Carcinoma Pathway, NCI Thesaurus/KEGG)
Individuals who have the heaviest constitutive pigmentation, especially dark skinned black individuals.
(Fitzpatrick Skin Type VI, NCI Thesaurus/CDISC)
This gene plays a role in the transforming growth factor-beta signal transduction pathway through constitutive kinase activity.
(ACVR2A Gene, NCI Thesaurus)
Both aberrant and constitutive activation of signal transduction molecules are found in about 50% of primary AML bone marrow samples, and seem to contribute to the increased proliferation and apoptosis resistance.
(Acute Myeloid Leukemia Pathway, NCI Thesaurus/KEGG)
These tumors frequently show a constitutive activation of the receptor tyrosine kinase-Ras pathway, exhibiting activating mutations in the HRAS and fibroblast growth factor receptor 3 (FGFR3) genes.
(Bladder Cancer Pathway, NCI Thesaurus/KEGG)
Individuals who have dark constitutive pigmentation but become noticeably darker with sun exposure, especially light complected black individuals, those of Indian descent.
(Fitzpatrick Skin Type V, NCI Thesaurus/CDISC)
In the absence of hedgehog, patched represses constitutive smoothened signaling through fused.
(Drosophila Patched Gene, NCI Thesaurus)
MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.
(MEK Inhibitor AZD8330, NCI Thesaurus)
High constitutive HMGA expression is consistently observed in cancers, with increasing concentrations being correlated with increasing malignancy.
(HMGA Family Gene, NCI Thesaurus)
These are inappropriately expressed and stimulate constitutive signaling, bypassing the need for receptor activation by growth factors.
(Papillary Thyroid Carcinoma Pathway, NCI Thesaurus/KEGG)
