CTCAE Grade 4 Oral Cavity Hemorrhage

Life-threatening consequences; major urgent intervention indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Oral Cavity GI Fistula

CTCAE Grade 4 Optic Disc Edema

Blindness (20/200 or worse)

CTCAE Grade 4 Opportunistic Infection

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Ophthalmoplegia and Diplopia

CTCAE Grade 4 Ocular Muscle Weakness Not Due to Neuropathy

CTCAE Grade 4 Obesity

BMI >=40 kg/m(2)