CTCAE Grade 4 Other Sexual Reproductive Function

Disabling (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Other Secondary Malignancy Possibly Related to Cancer Treatment

Solid tumor, leukemia or lymphoma

CTCAE Grade 4 Other Renal or Genitourinary

CTCAE Grade 4 Other Pulmonary and Upper Respiratory

CTCAE Grade 4 Other Pain

CTCAE Grade 4 Other Ocular and Visual

Blindness (20/200 or worse)

CTCAE Grade 4 Other NOS Vein Injury

Life-threatening; disabling; evidence of end organ damage