CTCAE Grade 4 Pharynx Pulmonary Fistula

Life-threatening consequences; operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Pharynx Obstruction and Stenosis

Life-threatening airway compromise; tracheotomy or intubation indicated

CTCAE Grade 4 Pharynx Necrosis

Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)

CTCAE Grade 4 Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification

Symptoms associated with life-threatening consequences

CTCAE Grade 4 Pharynx Mucositis or Stomatitis by Clinical Examination Classification

Tissue necrosis; significant spontaneous bleeding; life-threatening consequences

CTCAE Grade 4 Pharynx Leak

CTCAE Grade 4 Pharynx Intra-Operative Injury

Life threatening consequences; disabling