CTCAE Grade 4 Pleura Fistula

Life-threatening consequences; operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Platelets

<25,000/mm(3) <25.0 x 10e9 /L

CTCAE Grade 4 Pituitary Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Phrenic Nerve Dysfunction

Life-threatening respiratory compromise; mechanical ventilation indicated

CTCAE Grade 4 Photosensitivity

CTCAE Grade 4 Photophobia

CTCAE Grade 4 Pharynx Stricture or Stenosis

Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)