CTCAE Grade 4 Pneumothorax

Life-threatening, causing hemodynamic instability (e.g., tension pneumothorax); ventilatory support indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Pneumonitis and Pulmonary Infiltrates

Life-threatening; ventilatory support indicated

CTCAE Grade 4 Pleura Pain

CTCAE Grade 4 Pleura Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Pleura Infection with Unknown Absolute Neutrophil Count

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)