CTCAE Grade 4 Prolonged Intubation After Pulmonary Resection

Tracheostomy indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Prolonged Chest Tube Drainage or Air Leak After Pulmonary Resection

Life-threatening; debilitating; organ resection indicated

CTCAE Grade 4 Prolapse of Gastrointestinal Stoma

CTCAE Grade 4 Proctitis

Life-threatening consequences (e.g., perforation)

CTCAE Grade 4 Portal Vein Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Pneumothorax

Life-threatening, causing hemodynamic instability (e.g., tension pneumothorax); ventilatory support indicated

CTCAE Grade 4 Pneumonitis and Pulmonary Infiltrates

Life-threatening; ventilatory support indicated