CTCAE Grade 4 Rash Desquamation

Generalized exfoliative, ulcerative, or bullous dermatitis (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Radiation Excluding Chemoradiation

Skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site

CTCAE Grade 4 Pyramidal Tract Dysfunction

CTCAE Grade 4 PVCs

Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)

CTCAE Grade 4 Pulmonary Vein Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Pulmonary Hypertension

Symptomatic hypertension, poorly controlled

CTCAE Grade 4 Pulmonary Fibrosis Radiographic Changes

Estimated radiographic proportion of total lung volume that is fibrotic is >=75%; honeycombing