CTCAE Grade 4 Restrictive Cardiomyopathy

Refractory CHF, poorly controlled; intervention such as ventricular assist device, or heart transplant indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Respiratory Tract Hemorrhage NOS

Life-threatening consequences; major urgent intervention indicated

CTCAE Grade 4 Renal Failure

Chronic dialysis or renal transplant indicated

CTCAE Grade 4 Recurrent Laryngeal Nerve Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Rectum Ulcer

CTCAE Grade 4 Rectum Stricture or Stenosis

Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)

CTCAE Grade 4 Rectum Perforation