CTCAE Grade 4 Right Ventricular Dysfunction

Symptomatic cor pulmonale poorly controlled; intervention such as ventricular assist device, or heart transplant indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Retroperitoneum Hemorrhage

Life-threatening consequences; major urgent intervention indicated

CTCAE Grade 4 Retinopathy

Blindness (20/200 or worse)

CTCAE Grade 4 Retinoic Acid Syndrome

Life-threatening; ventilatory support indicated

CTCAE Grade 4 Retinal Detachment

Blindness (20/200 or worse)

CTCAE Grade 4 Retina Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Restrictive Cardiomyopathy

Refractory CHF, poorly controlled; intervention such as ventricular assist device, or heart transplant indicated