CTCAE Grade 4 Seizure

Seizures of any kind which are prolonged, repetitive, or difficult to control (e.g., status epilepticus, intractable epilepsy) (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Scrotum Pain

CTCAE Grade 4 Scrotum Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Scrotum Infection with Unknown Absolute Neutrophil Count

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Scrotum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Scleral Necrosis and Melt

Blindness (20/200 or worse); painful eye with enucleation indicated