CTCAE Grade 4 Slipped Capital Femoral Epiphysis

Disabling; severe slipped capital femoral epiphysis >60%; avascular necrosis (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Skin Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Skin Infection with Unknown Absolute Neutrophil Count

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Skin Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Skin Breakdown or Decubitus Ulcer

Life-threatening consequences; major invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)