CTCAE Grade 4 Stokes-Adams Syndrome

Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Splenic Function

CTCAE Grade 4 Spleen Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Spleen Infection with Unknown Absolute Neutrophil Count

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Spleen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Spine Scoliosis

Disabling (e.g., interfering with cardiopulmonary function)