CTCAE Grade 4 Stoma Perforation

Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Stoma Necrosis

Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)

CTCAE Grade 4 Stoma GI Stricture or Stenosis

Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)

CTCAE Grade 4 Stoma GI Obstruction

Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)

CTCAE Grade 4 Stokes-Adams Syndrome

Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)

CTCAE Grade 4 Splenic Function

CTCAE Grade 4 Spleen Intra-Operative Injury

Life threatening consequences; disabling