CTCAE Grade 4 Thyroid Function Low

Life-threatening consequences (e.g., thyroid storm)

Laboratory findings and life-threatening or disabling consequences, (e.g., CNS hemorrhage/bleeding or thrombosis/embolism or renal failure)

Embolic event including pulmonary embolism or life-threatening thrombus

Embolic event including pulmonary embolism or life-threatening thrombus

Life-threatening consequences; major invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)