CTCAE Grade 4 Trachea Fistula

Life-threatening consequences; operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Torsade de Pointes

Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)

CTCAE Grade 4 Tongue Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Tinnitus

CTCAE Grade 4 Thyroid Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Thyroid Function Low

Life-threatening myxedema coma

CTCAE Grade 4 Thyroid Function High

Life-threatening consequences (e.g., thyroid storm)