CTCAE Grade 4 Trunk Muscle Weakness Not Due to Neuropathy

Life-threatening; disabling (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Trigeminy

Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)

CTCAE Grade 4 Tremor

CTCAE Grade 4 Trachea Obstruction and Stenosis

Life-threatening airway compromise; tracheotomy or intubation indicated

CTCAE Grade 4 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification

Symptoms associated with life-threatening consequences

CTCAE Grade 4 Trachea Mucositis or Stomatitis by Clinical Examination Classification

Tissue necrosis; significant spontaneous bleeding; life-threatening consequences

CTCAE Grade 4 Trachea Intra-Operative Injury

Life threatening consequences; disabling