CTCAE Grade 4 Typhlitis

Life-threatening consequences (e.g., perforation, bleeding, ischemia, necrosis); operative intervention indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Trigeminy

Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)

CTCAE Grade 4 Tremor

CTCAE Grade 4 Trachea Obstruction and Stenosis

Life-threatening airway compromise; tracheotomy or intubation indicated