CTCAE Grade 4 Ulceration

Life-threatening consequences; major invasive intervention indicated (e.g., complete resection, tissue reconstruction, flap, or grafting) (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Typhlitis

Life-threatening consequences (e.g., perforation, bleeding, ischemia, necrosis); operative intervention indicated

CTCAE Grade 4 Tumor Pain

CTCAE Grade 4 Tumor Flare

CTCAE Grade 4 Trunk Muscle Weakness Not Due to Neuropathy

CTCAE Grade 4 Trigeminy

Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)

CTCAE Grade 4 Tremor