CTCAE Grade 4 Ureter Fistula

Life-threatening consequences; operative intervention requiring partial or full organ resection; permanent urinary diversion (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Upper Gastrointestinal Hemorrhage NOS

Life-threatening consequences; major urgent intervention indicated

CTCAE Grade 4 Upper Extremity Vein Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Upper Extremity Vein Injury

Life-threatening; disabling; evidence of end organ damage

CTCAE Grade 4 Upper Extremity Soft Tissue Necrosis Adverse Event

Life-threatening consequences; major invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)

CTCAE Grade 4 Upper Extremity Muscle Weakness Not Due to Neuropathy

CTCAE Grade 4 Upper Extremity Intra-Operative Injury

Life threatening consequences; disabling