CTCAE Grade 4 Valvular Heart Disease

Life-threatening; disabling; intervention (e.g., valve replacement, valvuloplasty) indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Vaginitis Not Due to Infection

Ulceration and operative intervention indicated

CTCAE Grade 4 Vaginal Mucositis

Tissue necrosis; significant spontaneous bleeding; life-threatening consequences

CTCAE Grade 4 Vagina Stricture or Stenosis

Life-threatening consequences; organ failure or operative intervention requiring organ resection indicated

CTCAE Grade 4 Vagina Perforation

Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated

CTCAE Grade 4 Vagina Pain

CTCAE Grade 4 Vagina Obstruction

Life-threatening consequences; organ failure or operative intervention requiring complete organ resection indicated