CTCAE Grade 4 Voice Changes and Dysarthria

Disabling; non-understandable voice or aphonic; requires voice aid (e.g., electrolarynx) for >50% of communication or requires >50% written communication (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Vital Capacity

<25% of predicted value

CTCAE Grade 4 Visceral Artery Injury

Life-threatening; disabling; evidence of end organ damage (e.g., stroke, MI, organ or limb loss)

CTCAE Grade 4 Viscera Vein Injury

Life-threatening; disabling; evidence of end organ damage

CTCAE Grade 4 Viral Hepatitis

Decompensated liver function (e.g., ascites, coagulopathy, encephalopathy, coma)

CTCAE Grade 4 Ventricular Tachycardia

Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)

CTCAE Grade 4 Ventricular Flutter

Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)