CTCAE Grade 4 Whole Body and Generalized Muscle Weakness Not Due to Neuropathy

Life threatening consequences; disabling

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

Disabling; non-understandable voice or aphonic; requires voice aid (e.g., electrolarynx) for >50% of communication or requires >50% written communication