CYP2C8*2 Allele

Human CYP2C8*2 allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, a variant form of the CYP2C8 wild-type allele, encodes cytochrome P450 2C8*2 protein. The CYP2C8*2 allele exhibits a clinically-relevant SNP (c.805A>T) in exon 5 that results in an I269F coding change. This sequence alteration in the cytochrome P450 2C8*2 protein increases the Km of this enzyme for paclitaxel, thereby decreasing the clearance of this drug. (NCI Thesaurus)

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CYP2C8 wt Allele

Human CYP2C8 wild-type allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, which encodes…

CYP2C8 Gene

This gene plays a role in drug metabolism. It is also involved in the oxidation of both endobiotics and xenobiotics.

CYP2C19*9 Allele

Human CYP2C19*9 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19…

CYP2C19*8 Allele

Human CYP2C19*8 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19…

CYP2C19*7 Allele

Human CYP2C19*7 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19…

CYP2C19*6 Allele

Human CYP2C19*6 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19…