CYP2C8*5 Allele

Human CYP2C8*5 allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, a variant form of the CYP2C8 wild-type allele, encodes cytochrome P450 2C8*5 protein. The CYP2C8*5 allele exhibits a clinically-relevant single nucleotide deletion (c.475delA), resulting in a coding frameshift that is predicted to cause amino acid alterations from codon 159 and an early stop codon at residue 477. The cytochrome P450 2C8*5 protein is predicted to be enzymatically inactive since it lacks 64% of the protein coding structure, a region which includes the heme binding site and 5 out of 6 substrate recognition sites. (NCI Thesaurus)

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CYP2C8*3 Allele

Human CYP2C8*3 allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, a variant form…

CYP2C8*2 Allele

Human CYP2C8*2 allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, a variant form…

CYP2C8 wt Allele

Human CYP2C8 wild-type allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, which encodes…

CYP2C8 Gene

This gene plays a role in drug metabolism. It is also involved in the oxidation of both endobiotics and xenobiotics.

CYP2C19*9 Allele

Human CYP2C19*9 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19…