| Health / Medical Topics |
Cytokeratin-8 Staining Method
An immunohistochemical technique to detect cytokeratin 8, an intermediate filament protein, using monoclonal antibody to cytokeratin 8. The antibody is useful in the detection of adenocarcinomas, mesotheliomas, and certain squamous epithelia-derived carcinomas. Specific combinations of cytokeratin peptides are associated with certain epithelial cells, and are therefore useful in the characterization of poorly differentiated carcinoma. The test is used as a clinically significant indicator in distinguishing carcinoma from malignant tumors of non-epithelial origin, such as lymphoma, sarcoma, and melanoma. (NCI Thesaurus)
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