DAG/PE-Binding Domain

The cysteine-rich N-terminal DAG/PE (Diacylglycerol/Phorbol Ester)-Binding (C1) Domain of PKC isoforms interacts with phorbol ester or with the phospholipid-derived second messenger diacylglycerol. C1 contains one or two copies of a Cys-rich domain about 50 amino-acid residues long; the domain binds two zinc ions, probably involving the conserved cysteines and histidines. Bound to DAG, C1 domains are involved in recruitment of proteins to the membrane via basic residues that interact with lipid head groups. Part of the domain contains two beta sheets that form a cavity and a short C-terminal alpha helix; another contains two zinc-binding sites that maintain the domain fold. Binding of diacylglycerol, or phorbol ester, to the domain results in modification of protein function. (NCI Thesaurus)

YOU MAY ALSO LIKE

Daflon 500

Daflon 500 is a phlebotonic drug and a vascular protecting agent. It is reported to improve microcirculation in chronic venous insufficiency…

DAD1 wt Allele

Human DAD1 wild-type allele is located 14q11.2 and is approximately 24 kb in length. This allele, which encodes dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1…

DAD1 Gene

This gene plays a role in peptide glycosylation.

DAD Questionnaire Question

A question associated with the DAD questionnaire.

DAD - Write and Convey a Telephone Message Adequately

Disability Assessment for Dementia (DAD) Write and convey a telephone message adequately?

DAD - Wash and Dry All Parts of Body Safely and Completely

Disability Assessment for Dementia (DAD) Wash and dry all parts of his/her body safely and completely?