Dasatinib

Pronunciation

Definition 1

A drug used to treat certain types of chronic myeloid leukemia and acute lymphoblastic leukemia. Dasatinib is also being studied in the treatment of certain other blood diseases and types of cancer. Dasatinib binds to and blocks BCR-ABL and other proteins that help cancer cells grow. It is a type of tyrosine kinase inhibitor. Also called BMS-354825 and Sprycel. (NCI Dictionary)

Definition 2

An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. (NCI Thesaurus)

YOU MAY ALSO LIKE

Darzalex

A drug used to treat multiple myeloma. It is used with dexamethasone and lenalidomide or bortezomib in patients whose cancer was treated…

Dartoic Muscle

The thin layer of smooth muscle surrounding the scrotum which contracts or expands the scrotal skin to regulate testicular temperature.

Dartoic Leiomyoma

A cutaneous leiomyoma arising from the dartos muscle of the scrotum or labia majora.

Dartmouth Regimen

A regimen consisting of tamoxifen, cisplatin, dacarbazine and carmustine used for the treatment of advanced-stage or metastatic malignant melanoma.

Darkly Pigmented Melanophages Present

A morphologic finding indicating the presence of darkly stained macrophages that contain melanin.

Dark-field microscope

A microscope (device used to magnify small objects) in which objects are lit at a very low angle from the side so…