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Demeclocycline hydrochloride
Pronunciation
Definition 1
A substance being studied as a way to detect bone growth in patients receiving bisphosphonates (a type of drug used to treat bone pain caused by some types of cancer) for breast cancer. It binds to newly formed bone. A biopsy is done and bone growth is measured using a special microscope. Demeclocycline hydrochloride is a type of tetracycline antibiotic and a type of bone-labeling agent. Also called Declomycin. (NCI Dictionary)
Definition 2
The hydrochloride salt of demeclocycline, a broad-spectrum, tetracycline derivative exhibiting antimicrobial, aquaretic and chelating activities. In bacteria, demeclocycline binds reversibly to the 30S ribosomal subunit and blocks the binding of aminoacyl-tRNA to the A-site of the mRNA-ribosome complex, resulting in the inhibition of protein synthesis and bacterial cell death. In mammals, this agent interferes with the action of antidiuretic hormone (ADH) at the level of the renal collecting tubule, resulting in aquaresis. In addition, demeclocycline, which like other tetracyclines chelates calcium in bone and exhibits a yellow fluorescence under ultraviolet (UV) light, may be used as a fluorescent bone-labeling agent in bone histomorphometry. (NCI Thesaurus)
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