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DEPLETION
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The act of decreasing something markedly
Classified under:
Nouns denoting acts or actions
Hypernyms ("depletion" is a kind of...):
decrease; diminution; reduction; step-down (the act of decreasing or reducing something)
Hyponyms (each of the following is a kind of "depletion"):
consumption; expenditure; using up (the act of consuming something)
exhaustion (the act of exhausting something entirely)
drain (a gradual depletion of energy or resources)
Derivation:
deplete (use up (resources or materials))
Sense 2
Meaning:
The state of being depleted
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("depletion" is a kind of...):
temporary state (a state that continues for a limited time)
Hyponyms (each of the following is a kind of "depletion"):
salt depletion (loss of salt from the body without replacement (loss by vomiting or profuse perspiration or urination or diarrhea) thus upsetting the electrolyte balance)
Derivation:
deplete (use up (resources or materials))
Context examples:
Inhibition of glycinamide ribonucleotide formyltransferase causes purine depletion and results in inhibition of DNA synthesis and cell cycle arrest.
(Glycinamide ribonucleotide formyltransferase inhibitor, NCI Thesaurus)
Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS.
(Parachloroamphetamine, NLM, Medical Subject Headings)
Depletion of arginine may lead to an inhibition of cellular proliferation in those cancer cells.
(Pegylated arginine deiminase, NCI Thesaurus)
Implicated mechanisms of action include decreased protein prenylation, activation of the peroxisome proliferation-activated receptors, inhibition of DNA methylation, and depletion of glutamine.
(Phenyl Acetate, NCI Thesaurus)
Other causes are: • Straining or overusing a muscle • Dehydration • A lack of minerals in your diet or the depletion of minerals in your body • Not enough blood getting to your muscles
(Muscle Cramps, NIH)
A morphologic and histochemical finding indicating depletion of mucin in the glands.
(Mucin Depletion, NCI Thesaurus)
Other cytotoxic mechanisms of action of this agent may involve thiol depletion, generation of reactive oxygen species (ROS), and decreases in the mitochondrial membrane potential.
(Imexon, NCI Thesaurus)
Therefore, this agent may be able to decrease the incidence of graft versus host disease (GVHD) via cytotoxic T-cell depletion.
(L-Leucyl-L-Leucine Methyl Ester, NCI Thesaurus)
Mitoclomine alkylates DNA and appears to concentrate primarily in the spleen and thymus where it causes lymphocyte depletion.
(Mitoclomine, NCI Thesaurus)
Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
(Alvespimycin, NCI Thesaurus)
