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GABA
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter
Synonyms:
GABA; gamma aminobutyric acid
Classified under:
Hypernyms ("GABA" is a kind of...):
amino acid; aminoalkanoic acid (organic compounds containing an amino group and a carboxylic acid group)
neurotransmitter (a neurochemical that transmits nerve impulses across a synapse)
Context examples:
This leads to an increase in the opening of chloride channels, membrane hyperpolarization, and increases the inhibitory effect of GABA on the CNS.
(Chlordiazepoxide Hydrochloride, NCI Thesaurus)
They increase the effect of a chemical in the brain called GABA, which is a neurotransmitter (a substance that nerves use to send messages to one another).
(Benzodiazepine, NCI Dictionary)
This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events.
(Alprazolam, NCI Thesaurus)
A hormone involved in sleep regulatory activity, and a tryptophan-derived neurotransmitter, which inhibits the synthesis and secretion of other neurotransmitters such as dopamine and GABA.
(Melatonin, NCI Thesaurus)
This agent may also interfere with the reuptake of GABA, thereby causing accumulation of GABA in the synaptic cleft.
(Midazolam hydrochloride, NCI Thesaurus)
The biogenic amines are neurotransmitters derived from amino acids, and include dopamine, epinephrine, GABA, histamine and serotonin.
(Neurotransmitter Biosynthesis Pathway, NCI Thesaurus/BIOCARTA)
Piperazine citrate is a gamma-aminobutyric acid GABA receptor agonist and blocks the activity of acetylcholine at the neuromuscular junction thereby altering neuronal cell membrane permeability and causing hyperpolarization.
(Piperazine Citrate, NCI Thesaurus)
Communication at these synapses happens when one neuron fires off packets of GABA molecules that are then quickly detected by proteins called GABA type A (GABAA) receptors on neighboring neurons.
(‘Sticky’ gene may help Valium calm nerves, National Institutes of Health)
In addition, through its primary metabolite phenylethylidenehyrazine (PEH), phenelzine causes elevated GABA levels in the caudate-putamen and nucleus accumbens thereby exerting its anxiolytic effects.
(Phenelzine Sulfate, NCI Thesaurus)
The gamma-aminobutyric acid (GABA) analogue baclofen appears to activate the inhibitory GABA(B) receptor, a G protein-coupled receptor, which may result in hyperpolarization of the neuronal cell membrane and inhibition of neurotransmitter release.
(Baclofen/amitriptyline/ketamine gel, NCI Thesaurus)
