| Health / Medical Topics |
Growth/Differentiation Factor 8
Growth Differentiation Factor 8, encoded by the human GDF8 gene, is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein plays a role in the control and maintenance of skeletal muscle mass. It acts specifically as a negative regulator of skeletal muscle growth by signaling through receptor serine/threonine kinases. This protein is synthesized as a preprotein activated by 2 proteolytic cleavages. Removal of the signal sequence is followed by cleavage at a tetrabasic processing site, resulting in a 26-kD amino-terminal propeptide and a 12.5-kD carboxy-terminal peptide, a dimer of which is the biologically active portion of the protein. (From LocusLink, OMIM and NCI) (NCI Thesaurus)
YOU MAY ALSO LIKE
Growth/differentiation factor 3 (364 aa, ~41 kDa) is encoded by the human GDF3 gene. This protein is involved in the modulation of…
Stature that is smaller than normal as expected for age.
A liquid or gel containing nutrients, salts, and other factors formulated to support the growth of microorganisms, cells, or plants.
A Screening Result captures the results of the tens of thousands of compounds screened for their ability to inhibit the growth of…
An adenoma or carcinoma of the anterior lobe of the pituitary gland that produces growth hormone.
A rare, hormonally functioning or non-functioning pituitary gland adenocarcinoma that produces growth hormone. It may be associated with acromegaly.
