Growth Differentiation Factor 9

Growth Differentiation Factor 9, encoded by the human GDF9 gene, is a member of the TGF-beta superfamily. This protein interacts with bone morphogenetic protein-15 and Bone morphogenetic protein receptor type II is a receptor for Growth Differentiation Factor-9. Both GDF9 mRNA and protein are abundantly expressed in oocytes of primary follicles in human ovary, suggesting that the GDF9 transcript is translated at this early stage of folliculogenesis. GDF9 is crucial for normal ovarian folliculogenesis and female fertility. GDF9 regulates human folliculogenesis in a manner specific to the ovary. A dysregulation of GDF9 expression may contribute to aberrant folliculogenesis in PCOS and PCO women. (From OMIM, Swiss-Prot and NCI) (NCI Thesaurus)

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