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Guanine Nucleotide Exchange Factor
Definition 1
GEFs. Proteins that catalyze the release and exchange of GDP for GTP from GTP-binding regulatory proteins, which are active in the GTP-bound form. The prototypical GEF is the eukaryotic initiation factor 2b, eIF-2B. Among other GTP-binding proteins regulated in this manner is p21 ras. (NCI Thesaurus)
Definition 2
proteins which catalyze GDP/GTP exchange. (NIH CRISP Thesaurus)
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