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HUNTINGTON
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A city of western West Virginia on the Ohio river at the mouth of the Kanawha
Classified under:
Nouns denoting spatial position
Instance hypernyms:
city; metropolis; urban center (a large and densely populated urban area; may include several independent administrative districts)
Holonyms ("Huntington" is a part of...):
Mountain State; W.V.; West Virginia; WV (a state in east central United States)
Sense 2
Meaning:
United States railroad executive who built the western section of the first United States transcontinental railroad (1821-1900)
Synonyms:
Collis Potter Huntington; Huntington
Classified under:
Instance hypernyms:
businessman; man of affairs (a person engaged in commercial or industrial business (especially an owner or executive))
Sense 3
Meaning:
American revolutionary leader who signed the Declaration of Independence and was president of the Continental Congress (1731-1796)
Synonyms:
Huntington; Samuel Huntington
Classified under:
Nouns denoting people
Instance hypernyms:
American Revolutionary leader (a nationalist leader in the American Revolution and in the creation of the United States)
Sense 4
Meaning:
United States physician who first described Huntington's chorea
Synonyms:
George Huntington; Huntington
Classified under:
Nouns denoting people
Instance hypernyms:
doc; doctor; Dr.; MD; medico; physician (a licensed medical practitioner)
Context examples:
Degenerative nerve diseases include: • Alzheimer's disease • Amyotrophic lateral sclerosis • Friedreich's ataxia • Huntington's disease • Lewy body disease • Parkinson's disease • Spinal muscular atrophy
(Degenerative Nerve Diseases, NIH)
This, together with the fact that it is known to play a role in Alzheimer’s, suggests that inflammation is part of many other neurodegenerative diseases, including Parkinson’s disease and Huntington’s disease.
(Inflammation in the brain linked to several forms of dementia, University of Cambridge)
Major types include: • Diseases caused by faulty genes, such as Huntington's disease and muscular dystrophy • Problems with the way the nervous system develops, such as spina bifida • Degenerative diseases, where nerve cells are damaged or die, such as Parkinson's diseaseand Alzheimer's disease • Diseases of the blood vessels that supply the brain, such as stroke • Injuries to the spinal cord and brain • Seizure disorders, such as epilepsy • Cancer, such as brain tumors • infections, such as meningitis
(Neurologic Diseases, NIH)
Huntington's disease is a neurodegenerative condition caused by a dominant mutation in a gene encoding a protein now called huntingtin.
(Inhibition of Huntington's Disease Pathway, NCI Thesaurus/BIOCARTA)
Huntington's disease (HD) is an inherited disease that causes certain nerve cells in the brain to waste away.
(Huntington's Disease, NIH: National Institute of Neurological Disorders and Stroke)
Felodipine was effective at reducing the build-up of aggregates in the mice with the Huntington’s and Parkinson’s disease mutations and in the zebrafish dementia model.
(Blood pressure drug shows promise for treating Parkinson’s and dementia in animal studies, University of Cambridge)
The lack of CBP in Huntington's affected neurons may lead to transcriptional repression of key genes that in turn leads to neurodegeneration.
(Inhibition of Huntington's Disease Pathway, NCI Thesaurus/BIOCARTA)
Also called: HD, Huntington's chorea
(Huntington's Disease, NIH: National Institute of Neurological Disorders and Stroke)
A prescription drug to treat high blood pressure has shown promise against conditions such as Parkinson’s, Huntington’s and forms of dementia in studies carried out in mice and zebrafish at the University of Cambridge.
(Blood pressure drug shows promise for treating Parkinson’s and dementia in animal studies, University of Cambridge)
One potential treatment being tested is the treatment of Huntington's affected individuals with histone deacetylase inhibitors to restore normal acetylation levels and transcription.
(Inhibition of Huntington's Disease Pathway, NCI Thesaurus/BIOCARTA)
